abstract：:The idiopathic inflammatory myopathies (IIMs) are a rare group of immune, systemic diseases characterised by muscle inflammation and frequently by extramuscular involvement. IIMs are heterogeneous with generally a chronic or subacute onset, which vary from less severe to more serious manifestations, not always easy to...

journal_title：Clinical and experimental rheumatology

authors： Tripoli A,Marasco E,Cometi L,De Stefano L,Marcucci E,Furini F,Barsotti S,Cavagna L

更新日期：2020-01-01 00:00:00

abstract：OBJECTIVES:To establish the weight of the subjective components of the Disease Activity index for Psoriatic Arthritis (DAPSA) in psoriatic arthritis (PsA) patients and comorbid fibromyalgia syndrome (FM). METHODS:In PsA patients not fulfilling the DAPSA remission, it has been calculated the DAPSA-patient (DAPSA-P), an...

journal_title：Clinical and experimental rheumatology

authors： Di Carlo M,Tardella M,Di Matteo A,Beci G,De Angelis R,Salaffi F

更新日期：2020-01-01 00:00:00

abstract：OBJECTIVES:Recently, research has been focused on the identification of predictors of response to treatment in patients with active psoriatic arthritis (PsA). The objective of this study was to develop a model to predict the clinical response at 6 months in patients with PsA starting the anti-tumour necrosis factor-α g...

journal_title：Clinical and experimental rheumatology

authors： Scrivo R,Giardino AM,Salvarani C,Foti R,Afeltra A,Viapiana O,Giacomelli R,Salaffi F,Galeazzi M,Ramonda R,Ciccia F,Valesini G,Iannone F,Predicting MDA in PsA Study Group.

更新日期：2020-01-01 00:00:00

abstract：OBJECTIVES:In a pilot study we aimed to identify biomarkers in repeated muscle biopsies and paired blood samples, taken before and after conventional immunosuppressive therapy, in order to predict long-term therapeutic response in patients with idiopathic inflammatory myopathies (IIM). METHODS:Muscle biopsies were sel...

journal_title：Clinical and experimental rheumatology

authors： Tang Q,Gheorghe KR,Zhang XM,Lindroos E,Alexanderson H,Wick C,Bruton M,Fernandes-Cerqueira C,Harris RA,Nennesmo I,Lundberg IE

更新日期：2020-01-01 00:00:00

abstract：OBJECTIVES:Giant cell arteritis (GCA) is a cause of potentially fatal aortic aneurysms. Descriptive data on thoracic aorta measurements at the beginning of the disease are lacking. We aimed to compare aortic diameters between a recently diagnosed GCA population and an age- and sex-matched control group. METHODS:Patien...

journal_title：Clinical and experimental rheumatology

authors： Rodrigues F,Abad S,Elourimi G,Le Jeune S,Mourad JJ,Warzocha U,Larroche C,Boissier MC,Bourgarit-Durand A,Brillet PY,Mekinian A,Soussan M,Dhote R

更新日期：2020-01-01 00:00:00

abstract：OBJECTIVES:To evaluate early and late responses in biological-naïve patients with rheumatoid arthritis (RA) initiating tocilizumab and early tocilizumab non-responders who switched to rituximab. METHODS:In this open-label, non-randomised phase 3 study, RA patients with inadequate response to conventional synthetic DMA...

journal_title：Clinical and experimental rheumatology

authors： Dörner T,Schulze-Koops H,Burmester GR,Iking-Konert C,Schmalzing M,Engel A,Kästner P,Kellner H,Kurthen R,Krüger K,Rubbert-Roth A,Schwenke H,Peters MA,Tony HP

更新日期：2019-11-01 00:00:00

abstract：OBJECTIVES:In this study, we used hypercholesterolaemic apolipoprotein E-deficient (Apoe-/-) mice to investigate LDL/oxLDL effect on synovial inflammation and cartilage destruction during antigen-induced arthritis (AIA). Further, as macrophage FcγRs are crucial to immune complex-mediated AIA, we investigated in vitro t...

journal_title：Clinical and experimental rheumatology

authors： Ascone G,Di Ceglie I,van den Bosch MHJ,Kruisbergen NNL,Walgreen B,Sloetjes AW,Lindhout E,Joosten LAB,van de Loo FAJ,Koenders MI,van der Kraan PM,Blom AB,van Lent PLEM

更新日期：2019-11-01 00:00:00

abstract：OBJECTIVES:Superior vena cava syndrome (SVCS) is a medical emergency which can also be seen in Behçet's syndrome (BS). Having noted that BS patients with SVCS frequently complained of sleep disturbances, snoring and sleep apnea, suggesting obstructive sleep apnea (OSA), we formally surveyed the risk for OSA among BS pa...

journal_title：Clinical and experimental rheumatology

authors： Gokturk A,Esatoglu SN,Atahan E,Hamuryudan V,Yazici H,Seyahi E

更新日期：2019-11-01 00:00:00

abstract：OBJECTIVES:This study evaluated the SDF-1/CXCL12 and soluble CXCR4 (sCXCR4) levels, and investigated their clinical relevance in adult-onset Still's disease (AOSD). METHODS:Forty-two AOSD patients and 30 healthy controls (HC) were enrolled for serum sampling. Expression levels of CXCL12 and CXCR4 in skin biopsy materi...

journal_title：Clinical and experimental rheumatology

authors： Han JH,Ahn MH,Jung JY,Suh CH,Kwon JE,Yim H,Kim HA

更新日期：2019-11-01 00:00:00

abstract：OBJECTIVES:Autonomic dysfunction (AD) has been described in various chronic inflammatory diseases. Studies of AD in patients with familial Mediterranean fever (FMF) are inconclusive. We aimed to assess AD in a cohort of FMF patients. METHODS:Signs and symptoms of AD were investigated in patients with FMF and compared ...

journal_title：Clinical and experimental rheumatology

authors： Moog P,Valda K,Eren OE,Rauschel V,Kossegg SJ,Bachmann Q,Schmaderer C,Straube A,Schulze-Koops H,Witt M

更新日期：2019-11-01 00:00:00

abstract：:Although osteoarthritis (OA) was historically referred to as the non-inflammatory arthritis, it is now considered a condition involving persistent low-grade inflammation and activation of innate inflammatory pathways. Synovitis increases the risk of OA onset and progression and involves the recruitment of monocytes, l...

journal_title：Clinical and experimental rheumatology

authors： Griffin TM,Scanzello CR

更新日期：2019-09-01 00:00:00

abstract：:Osteoarthritis (OA) is a disease of the whole joint, including synovium, bone and cartilage. OA is a slow degenerative and very heterogeneous disease, with both varying levels of disease activity and progression. Biomarkers are urgently needed to assist drug developers in selecting and developing the projects with the...

journal_title：Clinical and experimental rheumatology

authors： Karsdal MA,Henriksen K,Bay-Jensen AC

更新日期：2019-09-01 00:00:00

abstract：OBJECTIVES:To assess the efficacy and safety of tacrolimus in combination with corticosteroids in patients with immune-mediated necrotising myopathy. METHODS:The medical records of 20 hospitalised patients with immune-mediated necrotising myopathy (IMNM) who had received tacrolimus combined with oral prednisone from J...

journal_title：Clinical and experimental rheumatology

authors： Feng F,Li Y,Ji S,Wang Q,Bu B

更新日期：2019-09-01 00:00:00

abstract：:The latest revision of the European League Against Rheumatism (EULAR) recommendations for rheumatoid arthritis (RA) treatment maintains the indication for the combined therapy of biological disease-modifying antirheumatic drugs (bDMARDs) and targeted synthetic DMARDs (tsDMARDs), namely Jak-inhibitors as tofacitinib an...

journal_title：Clinical and experimental rheumatology

authors： Doria A,Zavaglia D

更新日期：2019-09-01 00:00:00

abstract：OBJECTIVES:The aim of this 2-year prospective study was to assess the diagnostic and therapeutic effect of a combined gastro-rheumatological approach in enteropathic spondyloarthritis (eSpA) patients. METHODS:Inflammatory bowel disease (IBD) patients with joint pain were referred by IBD-dedicated gastroenterologists t...

journal_title：Clinical and experimental rheumatology

authors： Chimenti MS,Conigliaro P,Triggianese P,Canofari C,Cedola F,Onali S,Calabrese E,Romeo S,Neri B,De Cristofaro E,Biancone L,Perricone R

更新日期：2019-09-01 00:00:00

abstract：OBJECTIVES:U1-70K, encoded by the SNRNP70 gene, is a key early immunogen in connective tissue disease. The aim of the study was the genetic analysis of the SNRNP70 gene in mixed connective tissue disease (MCTD), systemic lupus erythematosus (SLE) and systemic sclerosis (SSc) patients. METHODS:SNRNP70 genetic variants ...

journal_title：Clinical and experimental rheumatology

authors： Paradowska-Gorycka A,Wajda A,Stolarek I,Felis-Giemza A,Walczyk M,Nałecz-Janik J,Olesińska M

更新日期：2019-07-01 00:00:00

abstract：OBJECTIVES:In systemic sclerosis (SSc), B cell hyperactivation and abnormality are considered to play an important role in the disease pathophysiology. We aimed to clarify if the abnormal activation of B cells involves inhibitory FcγRIIB on B cells in SSc patients. METHODS:Blood samples were collected from 76 SSc pati...

journal_title：Clinical and experimental rheumatology

authors： Yagi-Numata N,Matsushita T,Takehara K,Hamaguchi Y

更新日期：2019-07-01 00:00:00

abstract：OBJECTIVES:Primary cardiac manifestation is a common complication of systemic sclerosis (SSc) with poor prognosis. The aim of the current study was to detect potential myocardial inflammation present in asymptomatic SSc patients by 18F-FDG-PET/CT and to investigate its relationship with early signs of myocardial dysfun...

journal_title：Clinical and experimental rheumatology

authors： Besenyi Z,Ágoston G,Hemelein R,Bakos A,Nagy FT,Varga A,Kovács L,Pávics L

更新日期：2019-07-01 00:00:00

abstract：OBJECTIVES:Obese patients with rheumatoid arthritis (RA) may be more likely to discontinue therapy than non-obese patients, possibly signifying a more refractory phenotype. The purpose of this study was to examine the association between body mass index (BMI) and discontinuation rates for different RA treatments accoun...

journal_title：Clinical and experimental rheumatology

authors： McCulley CB,Barton JL,Cannon GW,Sauer BC,Teng CC,George MD,Caplan L,England BR,Mikuls TR,Baker JF

更新日期：2019-05-01 00:00:00

abstract：OBJECTIVES:To analyse the worldwide occurrence of sicca/Sjögren's (SS) syndrome associated with the use of immune checkpoint inhibitors (ICI) in patients with cancer. METHODS:The ImmunoCancer International Registry (ICIR) is a Big Data-Sharing multidisciplinary network composed by 40 specialists in Rheumatology, Inter...

journal_title：Clinical and experimental rheumatology

authors： Ramos-Casals M,Maria A,Suárez-Almazor ME,Lambotte O,Fisher BA,Hernández-Molina G,Guilpain P,Pundole X,Flores-Chávez A,Baldini C,Bingham Iii CO,Brito-Zerón P,Gottenberg JE,Kostine M,Radstake TRD,Schaeverbeke T,Schulze-Koop

更新日期：2019-05-01 00:00:00

abstract：:In the era of personalised medicine new biomarkers are required to early diagnose Sjögren's syndrome (SS), to define different disease subsets and to direct patients' clinical management and therapeutic intervention. In the last few years, several efforts have evaluated saliva proteome to detect and monitor primary SS...

journal_title：Clinical and experimental rheumatology

authors： Cecchettini A,Finamore F,Puxeddu I,Ferro F,Baldini C

更新日期：2019-05-01 00:00:00

abstract：:Rheumatoid arthritis (RA) is a chronic, systemic inflammatory disease of unknown aetiology which principally affects the small joints of the hands and feet. The incidence of RA increases with age and peaks within the age range of 70 to 79 years. In the ageing population, therefore, it is expected that the number of pa...

journal_title：Clinical and experimental rheumatology

authors： Cleutjens FAHM,Boonen AERCH,van Onna MGB

更新日期：2019-05-01 00:00:00

abstract：OBJECTIVES:Interleukin-22 (IL-22) has been considered as an inflammatory cytokine. In the present study, we investigated the potential role of IL-22 in lupus nephritis (LN). METHODS:We examined the IL-22 levels of serum and kidney tissue from LN patients and MRL/lpr mice. An intraperitoneal injection of saline, isotyp...

journal_title：Clinical and experimental rheumatology

authors： Yang X,Weng Q,Hu L,Yang L,Wang X,Xiang X,Hong B,Gong X,Wang Q

更新日期：2019-05-01 00:00:00

abstract：OBJECTIVES:We propose a GCA probability score intended to help to risk-stratify patients referred by general practitioners with suspected GCA into those with high probability of GCA versus low probability of GCA. In this pilot study we evaluated the diagnostic accuracy of this proposed scoring system. METHODS:A scorin...

journal_title：Clinical and experimental rheumatology

authors： Laskou F,Coath F,Mackie SL,Banerjee S,Aung T,Dasgupta B

更新日期：2019-03-01 00:00:00

abstract：OBJECTIVES:To investigate the in-situ expression of acetylcholinesterase (AChE) in the inflamed vessel wall of patients with biopsy-positive giant cell arteritis (GCA) as compared to biopsy-negative non-GCA patients, and to evaluate the in-vivo expression of AChE in patients with large-vessel GCA (LVGCA) by 11C-donepez...

journal_title：Clinical and experimental rheumatology

authors： Therkildsen P,Nielsen BD,Hansen IT,Keller KK,Steiniche T,Gormsen LC,Borghammer P,Hauge EM

更新日期：2019-03-01 00:00:00

abstract：OBJECTIVES:The aim of the present study was to validate an Italian version of the GRAPPA flare instrument to identify patients with psoriatic arthritis (PsA) with a possible disease flare. METHODS:This was a cross-sectional study enrolling consecutively PsA patients classified with CASPAR criteria. Inclusion criteria ...

journal_title：Clinical and experimental rheumatology

authors： Scriffignano S,Perrotta FM,De Socio A,Altobelli A,Sessa P,Scrivo R,Valesini G,Lubrano E

更新日期：2019-03-01 00:00:00

abstract：OBJECTIVES:Neuromuscular efficiency (NME) is impaired in fibromyalgia (FM). Hyperbaric oxygen therapy (HBOT) is a medical treatment using 100% of oxygen through an oxygen mask. HBOT in FM induces changes in cortical excitability and a secondary reduction in pain and muscle fatigue. However, there are still no direct da...

journal_title：Clinical and experimental rheumatology

authors： Casale R,Boccia G,Symeonidou Z,Atzeni F,Batticciotto A,Salaffi F,Sarzi-Puttini P,Brustio PR,Rainoldi A

更新日期：2019-01-01 00:00:00

abstract：OBJECTIVES:The aims of this study were to define the risk of serious bacterial infections in patients receiving specific biological disease-modifying anti-rheumatic drugs (bDMARDs) and evaluating the effect of concomitant synthetic DMARDs (sDMARDs) in a large population-based sample of rheumatoid arthritis (RA) derivin...

journal_title：Clinical and experimental rheumatology

authors： Carrara G,Bortoluzzi A,Sakellariou G,Silvagni E,Zanetti A,Govoni M,Scirè CA

更新日期：2019-01-01 00:00:00

abstract：OBJECTIVES:To assess increased sacroiliac joint (SIJ) uptake on 18F-NaF PET/CT according to a qualitative and quantitative approach and to compare with MRI SIJ assessments for structural and inflammatory sacroiliitis in a population of 23 patients with spondyloarthritis (SpA) (IDRCB: 2012-A00568-35; ClinicalTrials.gov:...

journal_title：Clinical and experimental rheumatology

authors： Ouichka R,Bouderraoui F,Raynal M,Melchior J,Morel O,Blum A,Chary-Valckenaere I,Ngueyon Sime W,Roch V,Maksymowych W,Lambert RG,Olivier P,Loeuille D

更新日期：2019-01-01 00:00:00

abstract：OBJECTIVES:We investigated whether the central pain symptoms in fibromyalgia syndrome (FM) are related to defective top-down sensorimotor regulation. The pain matrix was activated in a top-down manner by presenting pictures of painful situations while recording brain activity using magnetoencephalography (MEG). We inve...

journal_title：Clinical and experimental rheumatology

authors： Goldstein A,Zeev-Wolf M,Herz N,Ablin JN

更新日期：2019-01-01 00:00:00

abstract：OBJECTIVES:Management of rheumatic diseases (RD) is often problematic in pregnant patients, hence the need for guideline implementation. This survey-based study aimed to assess beliefs among obstetricians and rheumatologists about managing RD in pregnant Lebanese patients. METHODS:Questionnaires were completed by a re...

journal_title：Clinical and experimental rheumatology

authors： Fayad F,Ziade N,Karam GA,Ghaname W,Khamashta M

更新日期：2018-11-01 00:00:00

abstract：OBJECTIVES:To validate the diagnostic benefit of dual-energy computed tomography (DECT) and synovial fluid aspiration in suspected gout. METHODS:A total of 43 patients with suspected gout underwent aspiration and DECT (320-row CT; Canon Medical Systems, Japan). The patients were assessed (gout vs. non-gout) based on t...

journal_title：Clinical and experimental rheumatology

authors： Nötzel A,Hermann KG,Feist E,Kedor C,Ziegeler K,Stroux A,Mews J,Schnorfeil M,Hamm B,Diekhoff T

更新日期：2018-11-01 00:00:00

abstract：OBJECTIVES:There is a drought of effective treatments of knee osteoarthritis (OA) and new therapies are needed. The present study has been conducted to establish an initial estimate of effectiveness of intra-articular (IA) injection of a proprietary 2.5% cross-linked polyacrylamide hydrogel (PAAG) for the treatment of ...

journal_title：Clinical and experimental rheumatology

authors： Henriksen M,Overgaard A,Hartkopp A,Bliddal H

更新日期：2018-11-01 00:00:00

abstract：OBJECTIVES:To determine the types and to assess the role of auditory evoked potentials and otoacoustic emissions in early detection of hearing abnormalities in Behçet's disease (BD) patients. Their correlations with disease activity were also considered. METHODS:Thirty patients with BD and thirty apparently sex- and a...

journal_title：Clinical and experimental rheumatology

authors： Nada DW,El Khouly RM,Gadow SE,Hablas SA,Aboelhawa MA,Al Ashkar DS,El Barbary AM,Hussein MS,Rageh E,Elsalawy AM,Abo-Zaid MH,Elshweikh S,El Gharib AM

更新日期：2018-11-01 00:00:00

abstract：OBJECTIVES:Imaging plays a role in myositis assessment by detecting muscle changes indicative of pathology. This study was conducted to determine the ultrasonographic pattern of muscle involvement in patients with inclusion body myositis (IBM) through an assessment of muscle echointensity. METHODS:Sixty-two individual...

journal_title：Clinical and experimental rheumatology

authors： Albayda J,Christopher-Stine L,Bingham Iii CO,Paik JJ,Tiniakou E,Billings S,Uy OM,Burlina P

更新日期：2018-11-01 00:00:00

abstract：OBJECTIVES:The aim of our study was to investigate possible interaction of IL-17, TRAIL, and TNF-α in the modulation of osteoblast homeostasis in vitro, using human differentiated osteoblastic Saos-2 cells as in vitro model. METHODS:The effects of these cytokines on osteoblastic cell viability were assessed, by MTT as...

journal_title：Clinical and experimental rheumatology

authors： Di Benedetto G,Lempereur L,Valle D,Greco EA,Bernardini R,Lenzi A,Migliaccio S

更新日期：2018-11-01 00:00:00

abstract：OBJECTIVES:Patients with clinically evident autoimmune disease are at increased risk for premature cardiovascular disease (CVD). Markers of serological autoimmunity such as anti-nuclear antibodies (ANA) are found in approximately 25% of the general population. Yet, the vast majority will not develop clinical autoimmune...

journal_title：Clinical and experimental rheumatology

authors： Solow EB,Vongpatanasin W,Skaug B,Karp DR,Ayers C,de Lemos JA

更新日期：2018-11-01 00:00:00

abstract：OBJECTIVES:To evaluate by ultrasound (US) the frequency and reliability of peritenon extensor tendon inflammation (PTI) and intra articular synovitis (IAS) in metacarpophalangeal joints (MCPj) of psoriatic arthritis (PsA) patients. METHODS:27 PsA patients with clinical involvement of MCPj were consecutively included. ...

journal_title：Clinical and experimental rheumatology

authors： Macía-Villa C,Falcao S,Gutierrez M,Medina J,Hammer HB,De Miguel E

更新日期：2018-09-01 00:00:00

abstract：OBJECTIVES:Although the relationship between atherosclerosis and cognitive impairment has been studied and replicated, whether cognitive deficits in RA can be attributed to atherosclerotic changes is not well understood. This study investigated cognitive function in patients with RA and evaluated whether cognitive func...

journal_title：Clinical and experimental rheumatology

authors： Lee JH,Kim GT,Kim YK,Lee SG

更新日期：2018-09-01 00:00:00

abstract：OBJECTIVES:To identify inflammatory pelvic structures of patients with polymyalgia rheumatica (PMR) by magnetic resonance imaging (MRI) in detail, searching for a disease-specific pattern. METHODS:A total of 40 contrast-enhanced pelvic MRIs of patients with a clinical diagnosis of PMR was reviewed by an experienced mu...

journal_title：Clinical and experimental rheumatology

authors： Fruth M,Buehring B,Baraliakos X,Braun J

更新日期：2018-09-01 00:00:00